A Receptor Dependent-4D QSAR Approach to Predict the Activity of Mutated Enzymes

Screening and selection tools to obtain focused libraries play a key role in successfully engineering enzymes of desired qualities. The quality of screening depends on efficient assays; however, a focused library generated with a priori information plays a major role in effectively identifying the right enzyme. As a proof of concept, for the first time, receptor-dependent – 4D Quantitative Structure-Activity Relationship (RD-4D-QSAR) has been implemented to predict the kinetic properties of an enzyme (Pravin et.al., July 2017).