Patents
In-silico guided CRISPR-Cas9 Driven Enzyme Engineering Technology (Kit); Easy and Fast way for Engineering Enzymes - Kcat has developed a new enzyme engineering (Patent No: 202141002674, 20thJAN-21) framework with Insilico guided CRISPR-CAS driven. This framework is combined with artificial intelligence for predicting hotspots and deriving a focussed library. Salient features of Kcat Enzymatic CRISPR-Cas9 Enzyme Engineering Technology(Kit):• The source gene (enzyme) of interest will be provided by Kcat Enzymatic• The kit...
Identification Of Hotspots And Derive Substitution For These Hotspots To Make Enzyme Variants And Screening These Enzyme Variants With Deep Learning Using A-CNN To Derive Top 5 Enzyme Variants With Desired Kinetic Property - The invention is specific to the engineering of enzymes. The Michaelis Complex of E-S reaction is simulated using QM/MM, and MD methods. Using the QM polarized grid maps, MMPBSA. MMGBSA, low energy ES conformations that lead to the formation of attack conformation are identified. Subsequently, the enzyme is designed around the Michaelis complex where the...
“7D-QSAR” INTEGRATED WITH QUANTUM MECHANICS A NOVEL TOOL FOR IMPROVING INDUSTRIAL ENZYMES, OUR NEW PATENT - The patented technology works on Quantum mechanics-based probes/grid points, and real solvation using semi-empirical QM simulations. The dynamic probes atoms in the grid are replaced based on the neighbor-neighbor contacts in the conformational transitions. The Dynamic grid points capture high-resolution details of the enzymatic reaction. The method was implemented on an R-specific transaminase enzyme and...
7D GRID ENZYME ENGINEERING ENGINE® - Kcat Enzymatic brings Enzyme Engineering & Biocatalysis Revolution by using upfront in-silico in-house developed methods and algorithms using 7D Grid Technology for enzyme engineering (Patent No: 201841047021). In this line, a new and advanced way of enzyme engineering methods were developed to use enzymes in industrial processes. Our multiscale methods and technologies gives custom engineered...
Binding Sites on Spike Protein and Cysteine Protease Mpro of Covid-19 and Identification of New Molecules Designed from Scaffolds and Pharmacophores of Phytochemicals and Synthetic Molecules that can act as Antivirals for Treatment of Covid-19 - The Coronavirus outbreak came to light on December 31, 2019 when China informed the World Health Organization. The growing COVID-19 global health crisis led us to contribute in scientific community. Kcat has contributed in identifying (Patent No: 202041038649, 08th Sep-20) antiviral compounds that can modulate the Cysteine protease Mpro and Spike protein of covid-19.
Treatment for Affections of Human Upper and Lower Respiratory Tract - A plant-derived composition of active ingredients of certain plant extracts is provided to treat the affections of the Human Upper and Lower Respiratory Tract. The invention applies to healing and curative effects of certain active ingredients in the extracts of plants such as Wilbrandia ebracteate, Plumbago zeylanica, Azadirachta indica, Juglans nigra, Eucalyptus globulus, Mentha piperita,...
7D QSAR Based Grid Maps Generated using Quantum Mechanic Probes to Identify Hotspots and Predict Activity of Mutated Enzymes for Enzyme Engineering - 7D Grid Technology uses Quantum Mechanic probes to “capture information across the enzymatic reaction and across the enzyme-substrate system”. This information is used by AI methods, Convolutional Neural Networks, and Support Vector Machines, to design enzymes and derive focused libraries. Based on the projects done in the last 2.5 years, we can say that promiscuous...