Algorithm to Predict Stereospecificity of Transaminase and its Enantiomeric Excess for a Given Substrate Using the Spatial Arrangement of Residues in the Active Site

A novel method to predict stereospecificity of Transaminases using spatial arrangement of residues in the active site and algorithm to predict ee% of transaminases for any given substrate. The study provides information on the molecular basis for engineering enzyme’s stereospecificity and a screening tool to derive focused libraries. (Under Review)