Enzyme engineering is a highly sophisticated and time intensive process. In order to complement in-vitro studies and streamline the screening process for the selection of enzyme variants, in-silico analyses provide a suitable platform, as various steps can be efficiently automated with little to no burden on time and resources. In this study, we provide a...
7D Grid Technology uses Quantum Mechanic probes to “capture information across the enzymatic reaction and across the enzyme-substrate system”. This information is used by AI methods, Convolutional Neural Networks, and Support Vector Machines, to design enzymes and derive focused libraries. Based on the projects done in the last 2.5 years, we can say that promiscuous...
The indirect flight muscles (IFMs) of Drosophila melanogaster provide a good model for understanding muscle development and function in vivo. We show that two missense mutations in the rod region of the myosin heavy-chain gene, Mhc, give rise to IFM defects and abnormal myofibrils. Molecular dynamics simulations suggest that these mutations may produce localized rod...
