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June 15, 2026
AN ARTIFICIAL INTELLIGENCE METHOD TO PREDICT SELECTIVITY OF TRANSAMINASES AND ENANTIOMERIC EXCESS OF TRANSAMINASE-KETONE REACTIONS

The present invention describes identifying if a given Transaminase is (R)-Selective or (S)-Selective. Based on the binding of the substrate in the active site of a given transaminase, it is primarily based on torsion, the angle between specific atoms of the cofactor PLP and the catalytic Lysine, and the ten interactions of the substrate with...